Rat Study Suggests Light at Night Might Hamper Breast Cancer Therapy

By Robert Preidt, HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- A study in rats hints that exposure to dim light at night may make human breast cancer tumors resistant to the chemotherapy drug doxorubicin.


However, giving the rats a melatonin supplement prevented this light-linked resistance to doxorubicin, the most widely used cancer chemotherapy drug in the world.


Prior rat-based research by the same investigators found that exposure to dim light at night boosted human breast cancer tumors' resistance to the breast cancer drug tamoxifen.


In the new study, rats with human breast cancer tumors were exposed to 12 hours of normal light followed by 12 hours of dim light, simulating dim light in a nighttime environment.


Half of the rodents were also given melatonin supplements during the dim light period.


Tumor growth in rats that did not receive melatonin was nearly triple that of those that did receive melatonin, the researchers reported. The researchers also found that tumors in rats that did not receive melatonin became completely resistant to doxorubicin, while tumors in rats that received melatonin remained sensitive to the chemotherapy drug and regressed rapidly.


The study was to be presented Monday at a meeting of the American Association for Cancer Research (AACR) in New Orleans. Experts note that findings in animals often fail to be replicated in humans, and studies presented at medical meetings are also considered preliminary until published in a peer-reviewed journal.


Still, the study's authors believe two enzymes may play a role in a resistance to doxorubicin that's tied to dim light at night.


"When we analyzed tumors from rats that did not receive nighttime melatonin supplementation, we detected substantially increased levels of two enzymes that break down doxorubicin to a less active form," Steven Hill, chair for breast cancer research at Tulane University School of Medicine in New Orleans, explained in an AACR news release.


He believes that an increase in the levels of these enzymes might speed the transport of doxorubicin away from cancer cells, "compared with tumors from rats receiving nighttime melatonin supplementation."


"Tumors from rats receiving nighttime melatonin supplementation had lower levels of these enzymes," Hill said. "So we think that melatonin helps maintain high levels of active doxorubicin in the cancer cells, whereas suppression of circadian melatonin production by exposure to light at night has the opposite effect."


More information


The U.S. National Cancer Institute has more about breast cancer treatment.


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Gene Study Finds No Proof Vitamin D Guards Against Type 2 Diabetes

By Robert Preidt, HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- There's no genetic evidence that high levels of vitamin D can prevent type 2 diabetes, a new study says.


Some previous research had suggested that elevated levels of vitamin D might protect people against type 2 diabetes, raising the possibility of a link between vitamin D deficiency and the blood sugar disease.


In this study, British researchers investigated the association between diabetes risk and vitamin D by focusing on genes that control blood levels of vitamin D. They found no connection between different variants of these genes and the risk of developing type 2 diabetes.


The results were published Sept. 30 in The Lancet Diabetes & Endocrinology.


"Our findings suggest that interventions to reduce the risk of type 2 diabetes by increasing concentrations of vitamin D are not currently justified. Observational studies that show a strong and consistent higher risk of type 2 diabetes with lower levels of vitamin D may do so because they have thus far not been able to adequately control for distorting or confounding factors, such as physical activity levels," study author Dr. Nita Forouhi, of the University of Cambridge's School of Clinical Medicine, said in a journal news release.


The findings add to evidence showing that taking vitamin D supplements does not prevent diabetes. The only proven ways to prevent type 2 diabetes are diet and exercise, Forouhi said.


One expert noted that long-term trials that are still looking at any possible connection should be weighed in the final analysis.


The results "need careful interpretation, and long-term randomized trials of vitamin D supplementation, which are underway, remain important," Dr. Brian Buijsse, from the German Institute of Human Nutrition Potsdam-Rehbruecke in Germany, wrote in an accompanying commentary in the journal.


"The results of an [analysis] of 35 short-term trials, however, do not offer much hope that vitamin D supplementation can be used to prevent type 2 diabetes. The sky is becoming rather clouded for vitamin D in the context of preventing type 2 diabetes," he said.


More information


The U.S. Office of Disease Prevention and Health Promotion explains how to prevent type 2 diabetes.


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Spacing Between Sibling Births Tied to Autism Risk in Study

By Robert Preidt, HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- Children conceived either less than one year or more than five years after the birth of a sibling could be at increased risk for autism, a new study suggests.


However, both the study's lead author and an outside expert agree that the research can't prove that birth spacing has any causative role in autism.


"Most importantly, it is important that parents understand that the odds for autism are still extremely low, even when pregnancies are close together or far apart," said outside expert Dr. Andrew Adesman. He is chief of developmental and behavioral pediatrics at Cohen Children's Medical Center of New York, in New Hyde Park, N.Y.


In the study, researchers analyzed data from more than 7,300 children born in Finland between 1987 and 2005. About one-third of the youngsters had been diagnosed with autism.


Compared to children conceived two to five years after the birth of a sibling, the risk of autism was 50 percent higher among those conceived less than a year after, nearly 30 percent higher among those conceived five to 10 years after, and 40 percent higher among those conceived more than 10 years after.


The study was published recently in the Journal of the American Academy of Child and Adolescent Psychiatry.


"It was intriguing to see that the risk of ASD [autism spectrum disorder] diagnosis was higher in both closely and distantly spaced pregnancies," study leader Keely Cheslack-Postava, of Columbia University in New York City, said in a journal news release.


However, she stressed, "it is important to realize that we can't say from this study that spacing of pregnancies per se is a cause of ASD -- this is most likely a proxy of other factors that are more directly related to the chance of the child's developing ASD."


Adesman agreed. "Although having a very short or very long interval between consecutive pregnancies may put the second child at some increased risk for an autism spectrum disorder, it is unclear why this is the case," he said.


"As researchers examine obstetric and environmental factors among children with an autism spectrum disorder, more and more apparent risk factors are identified," Adesman said.


"Although studies like this will likely lead to a greater understanding of the many factors that seem to be associated with ASDs, I can imagine women becoming more and more anxious or overwhelmed when it comes to minimizing their risk for a child with ASD," he added.


According to Cheslack-Postava, the real value of the finding lies in its potential relevance to autism research, not in any guideline as to when couples should have children.


"The importance of this finding lies in the clues that it can provide in terms of understanding how the prenatal environment is related to outcomes after birth," she explained.


More information


The U.S. National Institute of Neurological Disorders and Stroke has more about autism.


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Head Injuries May Raise Chances of Risky Behavior by Teens

By Dennis Thompson

HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- Teenagers who have experienced a traumatic brain injury are much more likely to engage in a wide range of risky behaviors, Canadian researchers report.


Both boys and girls were more likely to smoke, use drugs, drink alcohol and get poor grades after they endured a blow to the head that knocked them out for longer than five minutes or landed them in the hospital for a day or more, the study found.


"This is a wake-up call. Concussions are brain injuries, and we need parents and physicians to become more vigilant," said lead author Gabriela Ilie, a postdoctoral fellow at St. Michael's Hospital in Toronto. "Our brains define who we are, and a lot of our behaviors and thoughts and emotions depend on our brain circuitry operating properly."


However, the study only showed an association between traumatic brain injury and risky behaviors, not a cause-and-effect relationship, noted Dr. Anthony Alessi, a neurologist and concussion expert in Norwich, Conn.


Alessi said he is concerned that studies like these provide an easy excuse for bad personal choices.


"There are plenty of people who get hit in the head who have done very well for themselves," Alessi said. "I would hate for people to think once you've had a traumatic brain injury, you automatically will have all these other problems."


For their study, the Canadian researchers used data gathered during the 2011 Ontario Student Drug Use and Health Survey developed by the Center for Addiction and Mental Health in Toronto.


The survey, one of the longest ongoing school surveys in the world, contains responses from more than 9,000 students between grades 7 and 12 in public schools across Ontario.


The survey screened for traumatic brain injury by asking teens if they ever had a head injury that resulted in a loss of consciousness for at least five minutes or required them to spend at least one night in the hospital, Ilie said.


Girls and boys appear to react differently to brain injury, Ilie and her colleagues found.


Boys were three and a half times more likely to have bad grades, three times more likely to need medical treatment for a physical injury and twice as likely to use pot, compared with other boys who hadn't had a brain injury.


Meanwhile, girls were nearly four times more likely to have bad grades and three times more likely to smoke, compared to girls without a brain injury.


Female teens were more likely to engage in a wider range of risky behaviors following a brain injury than males, Ilie said.


For example, they were more likely to smoke cigarettes, endure bullying, think about suicide or suffer from anxiety or depression following their injury -- risks that were not associated with boys who had a brain injury.


"Both boys and girls were more likely to engage in a variety of harmful behaviors if they reported a history of TBI, but girls engaged in all 13 harmful behaviors we looked for, whereas boys were at higher risk of engaging in only nine," Ilie said. "Sex matters when it comes to traumatic brain injuries."


Researchers found that risks for some behaviors grew worse with age. For example, boys with a traumatic brain injury were twice as likely to smoke daily as they entered late adolescence. The number of girls using alcohol increased 20 percent as they left middle adolescence, reaching 89 percent between ages 17 and 20.


Dr. Sam Gandy, a professor of neurology and psychiatry at the Icahn School of Medicine at Mount Sinai in New York City, noted that one part of the brain is particularly vulnerable to injury.


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Social Support May Be Key to Heart Attack Recovery

By Robert Preidt, HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- Young and middle-aged heart attack survivors are more likely to have poor health and low quality of life if they have fewer family and friends to support them in their recovery, a new study suggests.


The study included more than 3,400 survivors, aged 18 to 55, who were assessed immediately after their heart attack and again one month and 12 months later.


The first assessment found that patients with low social support were more likely to be single, unemployed, live alone, smoke, abuse alcohol and to have heart risk factors such as high blood pressure, diabetes and depression.


One and 12 months after a heart attack, patients with low social support tended to have poorer mental health, more symptoms of depression and lower quality of life, according to the study published Sept. 30 in the Journal of the American Heart Association.


The findings are consistent with previous studies of older heart attack patients, and suggest the need for new ways of helping heart attack survivors.


"Studies like this are opening up a wide list of different types of risk factors than the ones we conventionally think about," senior study author Dr. Harlan Krumholz, director of the Center of Outcomes Research and Evaluation at Yale-New Haven Hospital in Connecticut, said in a journal news release.


"We shouldn't just be concerning ourselves with pills and procedures. We have to pay attention to things like love and friendship and the context of people's lives. It may be that these efforts to help people connect better with others, particularly after an illness, may have very powerful effects on their recovery and the quality of their lives afterwards," Krumholz said.


Lead researcher Emily Bucholz, a student in the school of medicine and the department of chronic disease epidemiology in Yale's School of Public Health, said that "this study adds to current literature by showing that there may be some utility in being able to identify patient support networks when patients are first hospitalized for heart attack."


Although the study found an association between social support and health outcomes after a heart attack, it did not prove a cause-and-effect relationship.


More information


The American Academy of Family Physicians has more about heart attack recovery.


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Acupuncture May Not Help Chronic Knee Pain, Study Finds

By Tara Haelle

HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- Acupuncture doesn't improve knee pain any more than "sham" acupuncture, according to a new study.


"Among patients older than 50 years with moderate to severe chronic knee pain, neither laser nor needle acupuncture conferred benefit over sham for pain or function," the study authors wrote. "Our findings do not support acupuncture for these patients."


Sham acupuncture is any form of fake acupuncture, used so that researchers can test whether benefits from the traditional acupuncture may be due to a placebo effect. A placebo effect means a person believes his symptoms have improved despite receiving a fake medication or treatment.


"Subjective measurements such as pain are particularly subject to placebo responses," said study co-author Kim Bennell, a professor of physiotherapy at the University of Melbourne in Australia. "This can be attributed to factors such as the treatment setting, patient expectations and optimism, the physician's confidence in the treatment, and how the physician and patient interact."


In this study, almost 300 adults with chronic knee pain received either needle acupuncture, laser acupuncture (hitting acupuncture spots with a low-intensity laser beam), sham laser acupuncture, or no treatment at all (the "control" group). With the sham treatment, a machine was pre-programmed not to deliver the laser, so neither the patient nor the acupuncturist knew it was a fake treatment.


Participants received 20-minute sessions up to twice a week for three months. They filled out questionnaires about their knee pain at the start of the study, three months later and one year later.


After three months, participants receiving needle, laser and sham acupuncture all experienced similar reductions in knee pain while walking, compared to the control group. The pain improvement was gone at a year, however, and the short-term improvements were too small to make a significant difference in practice, the authors wrote.


And, neither needle acupuncture nor laser acupuncture provided significantly greater relief than sham laser acupuncture, according to the study.


The patients who received needle acupuncture also experienced slightly improved physical function in their knees after three months compared to the control group, but it did not last a year, and a similar improvement was also seen in the sham group.


The findings were published in the Oct. 1 issue of the Journal of the American Medical Association.


This study was small, but its findings are similar to those of other acupuncture studies, according to Dr. Steven Novella, an assistant professor of neurology at Yale University School of Medicine. He said he was a little surprised that the difference between the treatment and control groups was not larger due to placebo effects.


"There are individual studies with weakly positive effects, but systematic reviews generally either show no effect at all or a slight effect that is not clinically significant," Novella said.


The lack of long-lasting pain relief from acupuncture in this study could be due to other reasons though, said Jean-Paul Thuot, an acupuncturist and owner of Stillpoint Community Acupuncture in Victoria, British Columbia in Canada.


"Osteoarthritis can often cause changes to the bone or joint structure," Thuot said. "If there are longstanding chronic changes to the structure, acupuncture will have a limited effect over such a short duration." Most of the people included in this trial had symptoms that could have been caused by osteoarthritis, according to the study.


He added that the acupuncture was also not provided often or long enough to see an effect.


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Could a 'Fat Tongue' Be a Factor in Sleep Apnea?

By Robert Preidt, HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- Sleep apnea is a potential health risk for millions of Americans, and a new study points to a possible culprit behind the disorder: a "fat" tongue.


"This is the first study to show that fat deposits are increased in the tongue of obese patients with obstructive sleep apnea," study senior author Dr. Richard Schwab, co-director of the Sleep Center at the University of Pennsylvania Medical Center, said in a news release from Sleep, which will publish the findings Oct. 1.


Sleep apnea is a common disorder in which the airways constrict during sleep, leading to repeated stops and starts in breathing. The telltale signs include chronic loud snoring, with periodic gasps or choking -- and, for many people, daytime drowsiness because of poor sleep.


But the effects go beyond fatigue. Studies suggest those pauses in breathing stress the nervous system, boosting blood pressure and inflammation in the arteries.


Obese people tend to be at higher risk for sleep apnea, and Schwab's team say the new findings may help explain the link between obesity and the breathing disorder.


The study included 90 obese adults with sleep apnea and 90 obese adults without the disorder.


The participants with sleep apnea had significantly larger tongues, tongue fat and percentage of tongue fat than those without sleep apnea, the researchers found. The tongue fat in the people with sleep apnea was concentrated at the base of the tongue.


In addition to increasing the size of the tongue, higher levels of tongue fat may prevent muscles that attach the tongue to bone from positioning the tongue away from the airway during sleep, Schwab's group explained.


While the study found an association between tongue fat content and sleep apnea, it could not prove cause and effect.


However, the researchers believe future studies should assess whether removing tongue fat through weight loss, upper airway exercises or surgery could help treat sleep apnea.


"Tongue size is one of the physical features that should be evaluated by a physician when screening obese patients to determine their risk for obstructive sleep apnea," American Academy of Sleep Medicine President Dr. Timothy Morgenthaler added in the news release.


"Effective identification and treatment of sleep apnea is essential to optimally manage other conditions associated with this chronic disease, including high blood pressure, heart disease, type 2 diabetes, stroke and depression," he said.


Nearly 35 percent of U.S. adults -- 78.6 million people -- are obese, according to the U.S. Centers for Disease Control and Prevention.


More information


The U.S. National Heart, Lung, and Blood Institute has more about sleep apnea.


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WATCH: Live From the 2014 Hospital of Tomorrow Conference

“Hospitals are at the center of a painful, messy, yet necessary disruption of the health care industry. The decisions made by leading institutions over the next year or so will have a profound effect on many lives.”

– Brian Kelly, Editor and Chief Content Officer of U.S. News & World Report, at Hospital of Tomorrow 2013.


During U.S. News & World Report's second annual Hospital of Tomorrow conference, experts and industry leaders will gather to discuss the challenges facing the hospital industry and share new thinking about the future of health care in the United States. If you can’t attend the conference from Oct. 6-8 in Washington, you can follow along on Twitter (#USNHOT14) or via live stream.


The keynote session on Monday, Oct. 6 will feature Michael E. Porter, the Bishop William Lawrence University Professor at Harvard Business School, speaking about value-based health care delivery. An executive roundtable discussion, "Navigating a New Era in Health Care," will follow. Participants include Carl S. Armato, president and CEO, Novant Health, Inc.; Gary S. Kaplan, M.D., chairman and CEO, Virginia Mason Health System; Elizabeth G. Nabel, M.D., president, Brigham and Women’s Hospital; and moderator Brad Kimler, executive vice president, Fidelity Investments.


Kaveh Safavi, M.D., global managing director, health industry, Accenture, and Gregory Sorensen, M.D., president and CEO, Siemens Healthcare North America, will offer keynote remarks.


The luncheon/keynote session on Tuesday, Oct. 7 will focus on The Changing Face of the Health Care Ecosystem, and From Real World Evidence to Real World Action: The Race for Better Health Care is the topic of the closing keynote session on Wednesday, Oct. 8.



Live Streaming Schedule


Monday, October 6


Tuesday, October 7


Wednesday, October 8



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What Happens to Patients When Mental Health Clinics Close?

Financial shortages have forced many states to cut millions of dollars from their mental health budgets, shuttering the community mental health clinics that serve as a safety net – or a last resort – for patients who have nowhere else to go. But after the clinics' doors are boarded up, what happens to the patients who are forced to find services elsewhere? It's hard to find definitive answers, academics and mental health workers say.


"There aren't empirical studies of this," says Linda A. Teplin, Owen L. Coon Professor of Psychiatry and Behavioral Sciences at Northwestern University’s Feinberg School of Medicine. "They're just too expensive to do, and not feasible. There are findings and government statistics that suggest what is happening,” but due to many complex variables, “nobody can do a direct study on the consequences of cuts for mental health."


Nevertheless, a few experts were able to share some common scenarios they've observed when access to public mental health centers is thwarted:



Patients Switch Providers
But They Often Don't Receive the Same Level of Care


When mental health clinics close, patients usually seek treatment at a new facility. People change doctors all the time, so what's the problem? Plenty, says Amy Watson, an associate professor at University of Chicago–Illinois’s Jane Adams College of Social Work who specializes in mental health policy.


"Whenever clinics close, there's [an interference] in care because [patients] may have an ongoing relationship with particular providers.” To develop new relationships with new providers, Watson says, "can be really disruptive."


Medical records can be transferred in the blink of an eye. But it takes much longer to open up to someone and feel comfortable talking about your symptoms, particularly if you have a stigmatized psychological disorder such as schizophrenia or bipolar disorder. Many patients have been visiting the same mental health providers for years, and it's difficult to develop the same kind of doctor-patient relationship overnight – especially when you only see them once a month. "It takes months before you're in a position where you might know that person, trust that person and feel comfortable with really working on things with them," Watson says. And with patients who have severe mental illnesses, "months" may be too long.


Patients aren't the only ones facing obstacles. Staff turnover at mental health clinics is high to begin with, Watson says, because the workers aren’t paid very much. And when mental health clinics close, even more therapists are laid off – making it that much harder for the few remaining mental health professionals to treat a new influx of patients. “Caseloads sometimes double or triple,” Watson says. “Initially there's this huge, inadequate capacity to serve the people who have been getting services."


When the therapists do see patients, it’s a challenge to implement individualized treatment. They have dozens of other people, each with varying conditions, to monitor on a regular basis. The appointments are shorter and more compressed. It’s also hard for them to return phone calls and schedule follow-up visits amid their jam-packed schedules. Perhaps the biggest obstacle, though, is maintaining a relaxed intimacy for patients. If they feel rushed, they won’t open up.


In short? Patients are forced to form new bonds with unfamiliar doctors, who might be highly skilled but are often too harried or transient to provide them with the attention they really need.


[Read: What You Need to Know About Schizophrenia .]


Some Patients Stop Seeking Regular Treatment


When mental health cuts are implemented, Watson says, patients are likely to face both physical and emotional obstacles when switching to a new provider.


The sheer act of traveling to a new health clinic can be an odyssey – especially for cultural and ethnic minorities and people below the poverty line, who are the population sector hit hardest by clinic closings. Many of these patients don’t own cars, and they might not have the money to subsidize lengthy commutes via public transportation. And if they work, it’s a challenge to squeeze a journey with multiple bus lines or subway routes into their schedule. Sometimes, the choice of whether or not to see a professional lies solely on whether they can afford the costs – or the time.


“It’s a safety issue also,” Watson says, explaining that many individuals with a mental illness have histories of trauma. “If they’re on a three-hour bus trip, it may be after dark. That could create such an anxiety situation that it’s easier to just stay home … They'll wait until [things are] really bad before they make the effort to figure out how to get help, and by then, you're talking about maybe emergency room use, hospitalization – those types of things.”


And there are still other potential roadblocks to care. Navigating cultural and language barriers is a huge factor, as some clinics are more prepared than others to receive new clients from disparate backgrounds. And since people with psychiatric illnesses often have concurrent conditions – substance abuse or another medical illness – throwing any change into their routine can complicate their goal to switch providers. All of these factors come into play when patients decide whether or not to keep on going to a clinic. Sometimes they brave the barriers. Other times, they decide it’s easier to just stay home – and their mental health pays the price.


[Read: How to Talk to Kids About Mental Illness .]


They End Up in Emergency Rooms – or Jails


When mental health clinics close, what usually follows are anecdotal reports of an increased amount of emergency hospitalizations and incarcerations, says Alexa James, executive director of Chicago’s chapter of National Alliance on Mental Illness, a nationwide grassroots nonprofit that provides treatment, support and advocacy for the mentally ill.


In 2012, Chicago closed six of its 12 mental health clinics for budgetary reasons – and former patients are still reeling from the effects, James says. “At NAMI, we’ve seen our support groups double,” James observes. “We’ve seen incarceration rates go up, and we saw hospitalization rates go up within the communities we work with” – although she notes that privacy laws and other factors keep them from knowing the numbers.


Cook County Sheriff Thomas Dart, who oversees Cook County Jail, the nation’s largest single site jail, made a similar observation. I talk to a lot of the detainees,” Dart says. “They frequently tell me, ‘They shut that clinic down that I used to go to all the time. Now I don't have anywhere to go, I’m off my meds now, [etc.]’ … People who traditionally never would've been in a criminal justice setting are now there by default.”


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Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors

By Alan Mozes

Health Day Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- Colon cancer patients who are overweight or obese when diagnosed appear to face a slightly higher risk for developing a second weight-related cancer, new research suggests.


The finding didn't speak to the risk of colon cancer recurrence, only the potential for developing other cancers associated with obesity.


"We found that colorectal cancer survivors who reported being overweight or obese prior to diagnosis had a modestly increased risk of developing an obesity-related second cancer compared to [cancer survivors] who reported a normal weight," said study lead author Todd Gibson, who conducted his research while a fellow with the U.S. National Cancer Institute.


A higher obesity-driven risk was identified for kidney, pancreatic, esophageal and endometrial cancers, as well as for postmenopausal breast cancer among female colorectal cancer patients.


Gibson, now an assistant faculty member at St. Jude Children's Research Hospital in Memphis, and his colleagues discussed the findings in the Sept. 29 online edition of the Journal of Clinical Oncology.


The authors noted that roughly 1.1 million Americans are living with colon cancer, and obesity has long been cited as a contributing risk factor for the disease.


However, in most cases colorectal cancer has a relatively high survival rate, with roughly 70 to 90 percent of patients living to the five-year mark following their diagnosis.


To assess how obesity might affect additional cancer risk post-survival, the research team focused on nearly 12,000 colon cancer survivors who were about age 69 on average when first diagnosed.


Patient weight had been assessed prior to their initial diagnosis by means of a body mass index calculation. BMI readings are based on height and weight.


In all, 44 percent of the patients were deemed overweight (a BMI between 25 and 29), while one-quarter were obese (a BMI of 30 or more).


When compared with colorectal cancer survivors who had been at "normal" weight at diagnosis, those who had been overweight or obese faced a greater risk for developing a second obesity-related cancer down the road.


However, the team stressed that the actual risk that an obese or overweight colon cancer survivor would develop a secondary cancer remained low, even if their relative risk was almost double that of normal-weight survivors.


Also, the risk for developing one of the obesity-related cancers was actually no higher among obese and overweight colon cancer survivors than it was for obese and overweight members of the general public who'd never had colon cancer.


In other words, the smoking gun appears to be obesity itself, rather than a prior history of cancer.


"The implication," said Gibson, "is that maintaining a healthy weight is important for cancer prevention in colorectal cancer survivors, just as it is in the general population. [So] our results further emphasize the importance of existing guidelines recommending healthy weight for survivors."


Dr. Andrew Chan, an associate professor in the department of medicine at Harvard Medical School in Boston, said the study "not only supports the importance of considering obesity as a risk factor for colorectal cancer, but also suggests that it remains a predictor of survival after one has been diagnosed."


The finding has "important implications as the average risk of developing colorectal cancer over one's lifetime is estimated to be about 6 percent," Chan said. "Thus, for this large number of individuals, working to maintain an ideal body weight remains a high priority."


Dr. David Carr-Locke, chief of the division of digestive diseases at Mount Sinai Beth Israel Medical Center in New York City, seconded the thought.


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Recessions May Thwart a Woman's Motherhood Plans Forever: Study

By Randy Dotinga

HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- When unemployment rates climb, women tend to put the brakes on motherhood. And for many young women, that decision may turn out to be a permanent choice, new research suggests.


Women in their early 20s appear most likely to choose not to have a child during tough economic times. But, according to the new study, that means many of those women will remain childless into their 40s and beyond.


The findings suggest that higher unemployment "will increase the numbers of unmarried, childless women," said study author Janet Currie, chair of Princeton University's department of economics and director of the Center for Health and Wellbeing.


"Perhaps the women will go on to have careers that they would not have had," said Currie, suggesting that these careers could interfere with plans to have children later in life.


"In the past, though, elderly unmarried women were more likely to be poor, and these women will not have children to depend on," she said.


Previous research has suggested that hard economic times may be linked to falling fertility rates. "The mystery is whether women make up for this by having more children later on," Currie said. So she and colleague Hannes Schwandt, a postdoctoral research associate at Princeton, decided to find out.


They examined the records of more than 140 million births in the United States from 1975 to 2010. Then they tried to find connections between birth rates, women of various childbearing ages and the unemployment rate.


"We find that women who were in their early 20s -- 20 to 24 -- during recessions reduced their fertility the most, and the effects were even greater in the long run," Currie said. "They were less likely to ever have married or to have had any children by age 40."


In the big picture, a recession is likely to be short and not have a huge impact on the country's birth rate, Currie said. Still, she added, the "Great Recession" of 2008-2009 will likely lower the number of births over the long term.


"The estimates imply that of the women aged 20 to 24 at the start of the Great Recession, an additional 151,082 will remain childless at age 40," the study authors wrote. That would represent an 8.9 percent increase in the number of women who remain childless for life, the researchers explained.


Two experts offered some theories on the study's findings.


"People may continue their education, for example, or take jobs that are not especially compatible with family life," said Andrew Foster, director of Brown University's Population Studies and Training Center.


"Or they may simply alter their expectations of what it means to be a family," Foster said. "These changes are not all good or all bad. But they do reflect a kind of response to the reduced opportunities that individuals face when they enter the labor market in a period of economic uncertainty."


Elizabeth Ananat, an assistant professor of public policy and economics at Duke University, said, "People often assume that boom and bust times cancel each other out. But this study reinforces earlier findings that the harm from recessions doesn't go away later, particularly for people who are in their early 20s and entering the job market for the first time when a recession hits."


The study was published in this week's issue of the Proceedings of the National Academy of Sciences.


More information


For more about infertility, visit the U.S. Centers for Disease Control and Prevention.


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Destination Wellness Programs: Too Good to be True?

Many of us – myself included – dream of visiting a wellness resort, where our sole focus is on ourselves. But do destination wellness programs work once you return home?


Among the many wellness programs that exist, a few are worth noting because they go beyond nutrition and fitness. These programs address the “whole” individual through strategic educational classes offered during the stay and, even more importantly, focus on emotional well-being instead of just physical changes.


While many people are familiar with the competitive and often dramatic “Biggest Loser” television series which debuted its 16th season in September, fewer realize the Biggest Loser Resorts offer everyday people the potential for long-term lifestyle changes with a structured wellness program. In addition to locations in Malibu, California and Niagara, New York, one new resort opened in Chicago in September and another will open in Jacksonville, Florida in October. The properties’ settings alone – like 1,350 acres at the top of a barrier island off the Northeast Florida coast – can serve as a muse for change.


[Read: Is 'Biggest Loser'-Style Weight Loss Healthy?]


According to Derek Johnson, executive nutrition director at Biggest Loser Resorts, what sets The Biggest Loser Resort program apart from other wellness resorts is a five-point philosophy that focuses on fitness, wellness, nutrition, relaxation and camaraderie. The goal of the program is to “provide guests with the tools they need to feel empowered,” both from emotional and physical standpoints, he says. It makes sense if you think about it: Many of us want to make the right decisions to lead a healthy lifestyle, but simply do not know how. The Biggest Loser Resort family says it offers both the resources and the emotional support for guests to finally flip the switch on their own journey.


[Read: How to Make Small Lifestyle Changes.]


While it is easy to imagine the changes that take place when someone guides you each day through your fitness and nutrition choices, how easy is it to continue that journey after your vacation has ended? I spoke to Johnson to find out more.


What is the No. 1 goal for guests coming to the Biggest Loser Resorts?


We hope that our guests feel empowered to create the healthy and balanced lifestyle that we know they deserve. Guests often arrive with blank stares and confusion, and our five-point philosophy teaches new patterns and tools to make long-term changes. One of the most rewarding things is to watch guests transform not just physically but also emotionally throughout their stay into a different shell of who they used to be. While it is inspiring to witness dramatic health changes in guests, emotional changes are powerful to witness. It is not uncommon to see guests who start the week not saying a word to anyone emerge as leaders by the end of their stay.


What should people be aware of when they leave the confines of a wellness destination and return home?


Many guests have been thinking about coming to the resort for years, but have put it off. There is a lot of fear – of food, of exercise and of the emotions that come with change. Often times, the struggles that individuals face during the week have to do with their fears, and those same fears can be factors when people return to their daily lives. We often say that tears weigh more than pounds, which is why there is so much focus on the emotional journey with the help of life coaches and wellness counselors.


[Read: Positive Emotional Psychology: Have a ‘Daily Diet’ of Positive Emotions.]


Before they leave the resort, we encourage guests to identify one goal at a time (from a list of seven keys to success) to work on at home. Trying two or three things at once does not work because you never know what is working or not. Consultations with our wellness team during the week are key to applying new learning to individual circumstances and to having the best chance of success at home.


Is there one change that has the most impact when returning to daily life?


For many, the biggest changes center around nutrition. I like to say that you are only as good as the foundation of your nutrition. Food has to be “on” to reach both physical and emotional goals. Because of that, one significant lifestyle change happens when you establish an eating pattern with a specific structure to meal times and snacks throughout the day.


[Read: How to Transform Your Nutrition Habits.]


Once at home, life can and will get in the way. One way to adjust to the variables of being home is to stay connected for support. Guests of the Biggest Loser Resorts can keep in touch with the wellness team through ongoing consultations. In addition to a binder full of resources, handouts and learning materials, in 2015, guests will be able to connect digitally with a new platform designed for ongoing communication. It is also important to create a local wellness team to help over the long haul. Changing your relationship with food, for example, can take months and months. Finding a local practitioner for support is crucial, especially when the demands of life, work and family distract us.


It is true that a trip to a destination wellness resort involves an investment of time, finances and emotional energy. But it is hard to argue with outcomes such as a healthier lifestyle and improved self-confidence.


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When It Comes to Sex Partners, Men Prefer Younger Women: Study

By Robert Preidt, HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- In books and movies, plots involving older men chasing much younger women abound.


Now, new research suggests that the stereotype may be grounded in fact.


In the study, psychologists looked at data on more than 12,000 people from Finland.


The researchers, led by Jan Antfolk of Abo Akademi in Turku, Finland, found that women typically preferred men who were the same age or somewhat older, and this remained consistent throughout their lives.


On the other hand, men tended to have a lifelong sexual preference for women in their mid-20s.


For example, men younger than 20 were typically attracted to older women, while men older than 30 began to prefer younger women.


According to the researchers this might be all part of Nature's plan: Men's heightened sexual interest in women in their mid-20s is probably because women are most fertile at this age, they said.


That kind of preference would have been an evolutionary advantage, because men who had sex with women in their mid-20s would have had more children than other men, Antfolk's team said.


For their part, women may be more selective than men about their sexual partners, which means they're more likely to have sex with partners who match their age preferences.


The bottom line? In the end, it may be women who most often get the upper hand in mate selection. According to the researchers, that's because men's actual sexual behavior is controlled more by women's selecting a mate based on her age preferences, rather than his own "age ideals."


The study was funded by the Academy of Finland and was published recently in the journal Evolutionary and Human Behavior.


More information


The U.S. National Library of Medicine offers resources about sexual health.


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Can Exercise Prevent Type 2 Diabetes? Your Genes May Be Key

By E.J. Mundell, HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- For millions of overweight Americans, regular exercise remains a prime weapon against excess weight and the threat of type 2 diabetes.


However, a new study suggests that the battle may be tougher for some than for others, depending on their genes.


"While physical activity generally promotes good health, it may not be as effective for everyone when it comes to preventing or treating type 2 diabetes," said one expert, Dr. Ruth Loos, director of the Genetics of Obesity and Related Metabolic Traits Program at the Icahn School of Medicine at Mount Sinai, New York City.


While it's long been known that physical activity can cut diabetes risk, the influence of genes on this protective effect hasn't been clear, according to background information from the study.


In the study, researchers led by Dr. Yann Klimentidis of the University of Arizona examined interactions between physical activity, genetics and diabetes risk in more than 8,100 white Americans, including 821 with type 2 diabetes.


They found that exercise provided less protection against diabetes in people at high genetic risk for diabetes and insulin resistance.


Insulin resistance, a precursor to full-blown diabetes, is a condition in which the body produces insulin but does not use it efficiently.


The study was published Sept. 29 in the journal Diabetologia.


While certain diabetes-linked genes seemed to blunt the benefits of exercise for both men and women, women seemed most affected, the Arizona team noted.


Loos, who is associate editor at Diabetologia and helped edit the paper, called the findings "important."


"This study suggests that especially those who are genetically prone [to diabetes] may need additional preventive measures and more targeted treatment," she said.


However, she also noted that the study had certain limitations.


"The scientists only studied sports participation, which is only a small component of people's overall daily physical activity," Loos said. "Furthermore, the role of a healthy diet, another important component in the prevention of type 2 diabetes, was not examined, either."


Dr. Minisha Sood is director of inpatient diabetes at Lenox Hill Hospital in New York City. She said that because the study only focused on white participants, its findings might not apply to a broader population of patients. However, Sood added that the general conclusion -- that genes may play a role in how effective exercise is in preventing diabetes -- makes intuitive sense.


And she stressed that the findings are no reason for people battling obesity to give up on exercise.


"Genetic predisposition to insulin resistance or not, physical activity has a multitude of health benefits --including perhaps delaying or mitigating insulin resistance," Sood said. "Being 'hardwired' for insulin resistance should not serve as a reason to give physical fitness and [maintaining a healthy weight] a low priority."


More information


The U.S. Office of Disease Prevention and Health Promotion explains how to prevent type 2 diabetes.


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Fish Oil Supplements Have Little Effect on Irregular Heartbeat: Study

By Steven Reinberg

HealthDay Reporter



TUESDAY, Sept. 30, 2014 (HealthDay News) -- High doses of fish oil supplements won't prevent the return of a common type of irregular heartbeat known as atrial fibrillation, Canadian researchers report.


In fact, 64.1 percent of those taking fish oil for its omega-3 fatty acids experienced new bouts of atrial fibrillation over the course of 16 months, compared to 63.2 percent of those taking a placebo. Fish oil supplements also did not reduce the twin ills of inflammation or oxidative stress, which may explain why they didn't guard against atrial fibrillation, the study authors noted.


"Fish oil has no role to play in the treatment of atrial fibrillation," said lead researcher Dr. Anil Nigam, an associate professor in the department of medicine at the University of Montreal.


Atrial fibrillation is a common malady in which the heartbeat is irregular and can race as fast as 150 beats a minute. A normal heart rate is around 70 beats a minute.


For the study, Nigam and his colleagues randomly assigned 337 patients with atrial fibrillation who were not being treated with medications to prevent the abnormal heart rhythm to 4 grams of fish oil a day or to a placebo. The patients were followed for up to 16 months.


The study, funded by the Canadian Institutes for Health Research and the Heart and Stroke Foundation of Quebec, was published online Sept. 29 in the Journal of the American College of Cardiology.


According to the Heart Rhythm Society, 2.7 million Americans suffer from atrial fibrillation, and that number is likely to increase as the population ages. The condition increases the risk of stroke fivefold and is responsible for 88,000 deaths each year.


Certain risk factors are associated with the development of atrial fibrillation, including obesity, high blood pressure, diabetes and sleep apnea, Nigam said. Some heart conditions, such as heart failure and heart valve problems, can also increase the risk of atrial fibrillation.


"For most people without heart problems, we believe a healthy weight and healthy lifestyle, and a good control of risk factors, can probably help reduce the risk of developing this condition, although this has not been studied per se," Nigam said.


He added that recent studies have found no benefit from fish oil supplements in people with heart disease who are being optimally treated and whose heart is working normally.


"However, people with poor heart function might still benefit from taking fish oil supplements," Nigam said. "What is better and should be recommended is a Mediterranean-type diet rich in natural omega-3 fats and other nutrients, including fresh fruits and veggies, legumes, olive oil, while lowering intake of red meat, trans fats and saturated fats," he said.


Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, said, "While some studies of omega-3 fatty acid supplementation have shown a modest benefit in treating patients with heart failure, there appears to be no benefit with omega-3 fatty acids in treating atrial fibrillation."


For patients with atrial fibrillation, prescribing traditional medications to prevent this abnormal heartbeat is the most common treatment. Patients may also need to take a blood thinner to help reduce the risk of stroke, he said.


In addition, some patients can benefit from a procedure called catheter ablation, which in essence, burns tiny sections of the heart to prevent the recurrence of atrial fibrillation, Fonarow added.


Preventing atrial fibrillation in the first place is a challenge, and much more research is needed, he noted.


More information


Visit the American Heart Association for more on atrial fibrillation.


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Families wait in agony for word on Ebola patients

By KRISTA LARSON, Associated Press


MONROVIA, Liberia (AP) — First the ring tone echoed outside the barbed-wire-topped walls of the Ebola clinic. Then came the wails of grief, as news spread that 31-year-old Rose Johnson was dead just days after she was brought here unconscious by relatives.


Soon her mother's sorrow became so unbearable, her body so limp and heavy, that even her two other daughters could no longer help her stand.


There had been no official confirmation of Rose's death from hospital officials, no time for someone to explain her final moments, just word from a family acquaintance inside who said her bed had been cleared that morning to make way for a new patient.


Her grieving husband stood in a daze outside the hospital, scratching air time cards so he could use his mobile phone to notify other family members.


"I've been here every day, every day, every day," says David Johnson, 31, now left with the couple's 18-month-old daughter Divine. "Up till now there has been no information. How can I believe she is dead?"


As the death toll from Ebola soars, crowded clinics are turning over beds as quickly as patients are dying. This leaves social workers and psychologists struggling to keep pace and notify families, who must wait outside for fear of contagion. Also, under a government decree, all Ebola victims must be cremated, leaving families in unbearable pain with no chance for goodbye, no body to bury.


"People are standing around for weeks. Nobody is coming to them. There should be a system in place for disseminating information but there is nothing," says Kanyean Molton Farley, a 39-year-old community leader in one of Monrovia's hardest-hit neighborhoods.


At least 1,830 people are believed to have died from the disease here in Liberia, and many fear the actual toll is far higher and rising fast. A recent update from the World Health Organization showed that more than half the cases in Liberia happened in the preceding 21 days.


Doctors Without Borders in Monrovia has three phone lines to answer calls from worried families. The group asks relatives to come in person for updates on their loved ones inside the 160-bed facility, but sometimes they get news from friends or family inside instead, says Athena Viscusi, a clinical social worker.


"We encourage them to come and meet with a counselor," says Viscusi. She notes that Doctors Without Borders hopes eventually to photograph the dead before cremation to help with identification.


Dozens of family members show up each day at the gates of the city's Ebola clinics, anxiously clutching cell phones and desperate for any update on their loved ones inside. They pace back and forth, leaving only to buy more phone credit. All the while, they keep a safe distance from those stricken with Ebola who huddle by the gates in hopes of gaining a coveted bed inside and a chance at life.


Linda Barlea, 32, is desperate to know what has become of her boyfriend of 13 years. One by one his family has been decimated by Ebola: First his brother, then his mother, then a sister, then another brother. Only the 7-year-old niece Miamu has survived, and then was chased from Barlea's home by fearful neighbors.


Barlea's mother called the clinic's official hotline for patient information and was told his name appeared on the list of the dead. Barlea says she needs to hear it for herself. But every time she calls now, she gets a busy signal. So she has shown up here, demanding answers before she will leave.


The lack of official confirmation has led to disastrous misinformation in some cases: Julius Prout's family held two wakes for him after being told by a security guard at the clinic that he was dead. Family members gathered first for several days at his parents' home, then at his uncle's.


Instead, health workers had merely moved him to another section of the hospital and burned his cell phone along with his belongings for fear of contamination.


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Doctors' Group Issues Painkiller Guidelines

By Robert Preidt, HealthDay Reporter



MONDAY, Sept. 29, 2014 (HealthDay News) -- The risks of powerful narcotic painkillers outweigh their benefits for treating chronic headaches, low back pain and fibromyalgia, a new statement from the American Academy of Neurology says.


Narcotic, or opioid, painkillers include medications such as morphine, codeine, oxycodone (Oxycontin), methadone, fentanyl, hydrocodone or a combination of the drugs with acetaminophen.


The drugs can cause serious side effects, overdose, addiction and death. Research shows that 50 percent of patients who took opioids for at least three months are still on them five years later, according to the academy.


Studies find that while opioids may provide short-term pain relief, there is no proof that they maintain pain relief or improve patients' ability to function over long periods of time without a serious risk of overdose, dependence or addiction, the statement says.


"More than 100,000 people have died from prescription opioid use since policies changed in the late 1990s to allow much more liberal long-term use," Dr. Gary Franklin, of the University of Washington in Seattle, said in an academy news release.


"There have been more deaths from prescription opioids in the most vulnerable young to middle-aged groups than from firearms and car accidents," he added. "Doctors, states, institutions and patients need to work together to stop this epidemic."


Doctors should consult with a pain management specialist if a patient's daily opioid dosage reaches 80 milligrams to 120 milligrams, especially if the patient isn't showing substantial improvement in pain levels and physical function, the statement advises.


The statement, published in the Sept. 30 issue of the journal Neurology, also outlines ways for doctors to prescribe opioids more safely and effectively. These suggestions include: screening for depression and current and past drug abuse; creating an opioid treatment agreement with the patient; and using random urine drug screenings.


"More research and information regarding opioid effectiveness and management is needed, along with changes in state and federal laws and policy to ensure that patients are safer when prescribed these drugs," Franklin said.


More information


The American Academy of Family Physicians has more about chronic pain medicines.


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Too Many Heart Scans May Pose Radiation Risks, Cardiologists Say

By Robert Preidt, HealthDay Reporter



MONDAY, Sept. 29, 2014 (HealthDay News) -- Doctors need to make sure patients understand the radiation-related risks of heart imaging tests before sending them for such procedures, a new American Heart Association scientific statement says.


"With technological improvements, medical imaging has become an increasingly vital tool in diagnosing and treating patients with heart disease, but the rising use of the tests has led to increasing radiation exposure over the past two decades," Dr. Reza Fazel, chair of the statement writing committee and a cardiologist at Beth Israel Deaconess Medical Center in Boston, said in an association news release.


"Heart imaging procedures account for almost 40 percent of the radiation exposure from medical imaging," Fazel said.


Before referring a patient for a heart imaging test, the cardiologists say, doctors need to address questions such as:



  • How will the test help diagnose or treat the heart problem?

  • Are there alternatives that don't use radiation?

  • What are the levels of radiation exposure, how will it affect the risk of cancer later in life and how does that compare to the risk from other common activities?


"In general, the radiation-related risk of any imaging test to an individual patient is very small and, when the test is clinically appropriate, the benefits of the test typically far outweigh any potential risks," Fazel said.


Doctors who order heart imaging tests need to understand when each type of test is appropriate, the typical average radiation dose and the potential risks, according to the statement published Sept. 29 in the journal Circulation.


"Radiation-related risk is one of the factors that should be considered in the decision to use cardiovascular imaging with ionizing radiation, particularly in younger patients in whom the potential risk of radiation exposure is thought to be higher," Fazel added.


When deciding on a heart imaging test, doctors also need to consider the test's diagnostic accuracy, availability, cost, convenience and other potential risks.


Widely used types of heart imaging tests that use radiation include nuclear stress tests, cardiac CT scans, and fluoroscopy. Fluoroscopy is a technique that uses X-rays to create "real-time" or moving images of the body. Ultrasound and MRI tests do not expose patients to radiation.


More information


The U.S. National Library of Medicine has more about medical imaging tests.


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Antibiotic Use Before Age 2 Might Raise Obesity Risk, Study Says

By Kathleen Doheny

HealthDay Reporter



MONDAY, Sept. 29, 2014 (HealthDay News) -- Children who are given broad-spectrum antibiotics before the age of 2 may face a slightly higher risk of becoming obese during childhood, new research suggests.


Broad-spectrum antibiotics target a larger number of organisms than narrow-spectrum ones, according to the study.


"It is a reason to think about whether you need antibiotics, and which antibiotic you are picking," said lead researcher Dr. Charles Bailey, attending physician at Children's Hospital of Philadelphia and an assistant professor of clinical pediatrics at the University of Pennsylvania.


Bailey and his colleagues looked at the health records of nearly 65,000 children who were seen at clinics from 2001 through 2013. The researchers followed the children from birth to age 5. They tracked the height and weight of the children, and classified them as normal weight, overweight or obese.


The study authors found that 69 percent of the children were given antibiotics before age 2. On average, the children had 2.3 episodes of antibiotic use.


Children who had four or more exposures to antibiotics were 11 percent more likely to be obese than those who did not. The researchers also looked at whether the antibiotics prescribed were narrow-spectrum, which are recommended as first-line treatment of common childhood infections, or broad-spectrum. "Kids who got broad-spectrum antibiotics had a 16 percent higher risk [of obesity than those who did not]," Bailey said.


No link was found between the narrow-spectrum drugs and obesity risk.


The researchers took into account other factors affecting obesity, such as insurance status, use of steroids and having an asthma diagnosis, and the association held.


The study was published in the Sept. 29 online edition of the journal JAMA Pediatrics.


Bailey and his team decided to look at the possible link between early antibiotic use and obesity risk because previous research has suggested that a person's intestinal microbe environment may be linked with obesity; antibiotic use may affect that environment.


"What we see here is an association," Bailey said. "We haven't proven cause and effect," he explained.


"For most kids, obesity is not the result of one thing they do or don't do," he said. And the 16 percent higher risk is not great, he acknowledged, but the many factors that may drive obesity risk add up.


Parents can ask a doctor who is recommending their young child take an antibiotic if the treatment is really needed. If it is, parents can ask if a narrow-spectrum antibiotic would do the job.


The study was funded by an unrestricted donation from the American Beverage Foundation for a Healthy America to the Children's Hospital of Philadelphia to support the hospital's Healthy Weight Program. The Healthy Weight Program directly funded the study, Bailey said.


The risk found is relatively small, but the finding is "certainly one more reason to be concerned that we should use [antibiotics] more carefully and more prudently," said Dr. Andrew Pavia, chief of pediatric infectious diseases at the University of Utah School of Medicine, in Salt Lake City.


If children really need an antibiotic, he said, "the good outweighs the harm."


He suggested asking these questions if your child's doctor is suggesting an antibiotic: "Do I really need [to give my child] an antibiotic or could we wait another day and see?" or "Is this the most narrow-spectrum to do the job?"


More information


To learn more about antibiotics, visit the U.S. Centers for Disease Control and Prevention.


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Rat Study Suggests Light at Night Might Hamper Breast Cancer Therapy

By Robert Preidt, HealthDay Reporter



MONDAY, Sept. 29, 2014 (HealthDay News) -- A study in rats hints that exposure to dim light at night may make human breast cancer tumors resistant to the chemotherapy drug doxorubicin.


However, giving the rats a melatonin supplement prevented this light-linked resistance to doxorubicin, the most widely used cancer chemotherapy drug in the world.


Prior rat-based research by the same investigators found that exposure to dim light at night boosted human breast cancer tumors' resistance to the breast cancer drug tamoxifen.


In the new study, rats with human breast cancer tumors were exposed to 12 hours of normal light followed by 12 hours of dim light, simulating dim light in a nighttime environment.


Half of the rodents were also given melatonin supplements during the dim light period.


Tumor growth in rats that did not receive melatonin was nearly triple that of those that did receive melatonin, the researchers reported. The researchers also found that tumors in rats that did not receive melatonin became completely resistant to doxorubicin, while tumors in rats that received melatonin remained sensitive to the chemotherapy drug and regressed rapidly.


The study was to be presented Monday at a meeting of the American Association for Cancer Research (AACR) in New Orleans. Experts note that findings in animals often fail to be replicated in humans, and studies presented at medical meetings are also considered preliminary until published in a peer-reviewed journal.


Still, the study's authors believe two enzymes may play a role in a resistance to doxorubicin that's tied to dim light at night.


"When we analyzed tumors from rats that did not receive nighttime melatonin supplementation, we detected substantially increased levels of two enzymes that break down doxorubicin to a less active form," Steven Hill, chair for breast cancer research at Tulane University School of Medicine in New Orleans, explained in an AACR news release.


He believes that an increase in the levels of these enzymes might speed the transport of doxorubicin away from cancer cells, "compared with tumors from rats receiving nighttime melatonin supplementation."


"Tumors from rats receiving nighttime melatonin supplementation had lower levels of these enzymes," Hill said. "So we think that melatonin helps maintain high levels of active doxorubicin in the cancer cells, whereas suppression of circadian melatonin production by exposure to light at night has the opposite effect."


More information


The U.S. National Cancer Institute has more about breast cancer treatment.


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Obese in Adolescence, Colon Cancer in Later Life?

By Steven Reinberg

HealthDay Reporter



MONDAY, Sept. 29, 2014 (HealthDay News) -- Obesity and inflammation in late adolescence are associated with increased risk for colon and rectal cancer in adulthood, a new study of Swedish males suggests.


The 35-year study found that 16- to 20-year-olds who were obese had more than twice the risk of developing colon or rectal cancer compared to normal-weight teens.


And teens with high levels of inflammation had a 63 percent increased risk of developing colorectal cancer, compared with those with low levels of inflammation, researchers found.


"These results are important because we know relatively little about the role of early life exposures in the development of colon cancer," said lead researcher Elizabeth Kantor, a postdoctoral research fellow in the department of epidemiology at the Harvard School of Public Health in Boston.


However, Kantor said this study doesn't prove that obesity and inflammation in adolescence caused the increased risk for colorectal cancer.


"We are talking about associations and cannot say whether or not they are causal," she said. "For this reason, I think it's important to be cautious with the conclusions of the study," she added.


For one thing, nothing was known about the diets of the boys studied, the researchers noted.


Obesity is thought to be a cause of inflammation, which has been associated with an increased risk for a variety of cancers, according to the American Cancer Society.


The study findings were scheduled for presentation Monday at a meeting of the American Association for Cancer Research in New Orleans.


Dr. Andrew Chan, an associate professor in the department of medicine at Harvard Medical School, said there is "pervasive evidence" that obesity is a risk factor for colon cancer.


It isn't clear, however, when obesity matters the most, he said. "We know that the development of colon cancer takes many years. So it is important to understand whether it's obesity earlier or later in life that is more influential," Chan said.


Kantor agreed that more work is needed to determine how obesity and inflammation might influence colorectal cancer risk at different stages in life.


For the study, Kantor's team analyzed data on nearly 240,000 Swedish males drafted into the military from 1969 to 1976 when they were between 16 and 20 years of age.


When they were inducted into the military, the men underwent a blood test to measure inflammation in their body and had their height and weight recorded.


To identify men with colorectal cancer from this group, the researchers linked draft records with a national cancer registry. By the start of 2010, the investigators found that 501 men had developed colon cancer and 384 had developed rectal cancer.


Obesity was associated with 2.37 times greater risk of developing colorectal cancer, the researchers said.


Dr. David Katz, director of the Yale University Prevention Research Center, wasn't surprised by the findings. "We have long known that obesity is associated with an increased risk of almost all cancers, and obesity is associated with inflammation," he said.


Establishing healthful eating and physical activity patterns in childhood is crucial, he said. "A healthy lifestyle is the best defense we have against obesity, inflammation, and the dangers these portend over a lifetime," he said.


Data and conclusions presented at meetings are typically considered preliminary until published in a peer-reviewed medical journal.


More information


For more about obesity and cancer, visit the U.S. National Cancer Institute.


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Emotional Life Lingers for Alzheimer's Patients, Even as Memory Fades

By Robert Preidt, HealthDay Reporter



MONDAY, Sept. 29, 2014 (HealthDay News) -- For those visiting a person with advanced Alzheimer's, the moment can be bittersweet -- will the patient even remember or care that the loved one was there?


Now, a new study suggests that even if people with the mind-robbing illness quickly forget a visit or other event, the emotions tied to the experience may linger.


The study included 17 Alzheimer's patients who watched 20-minute clips of either happy or sad movies.


Even though their memories of the films quickly faded, the patients' feelings of happiness and sadness associated with the movies lingered for up to 30 minutes, the researchers reported.


The study suggests that caregivers can have a significant effect, for good or bad, on the emotional state of Alzheimer's patients. They may not remember a loved one's visit -- or being abused or neglected by nursing home staff -- but there is a lasting emotional impact, the researchers believe.


"This confirms that the emotional life of an Alzheimer's patient is alive and well," study author Edmarie Guzman-Velez, a doctoral student in clinical psychology at the University of Iowa, said in a university news release.


"Our findings should empower caregivers by showing them that their actions toward patients really do matter," she added. "Frequent visits and social interactions, exercise, music, dance, jokes and serving patients their favorite foods are all simple things that can have a lasting emotional impact on a patient's quality of life and subjective well-being."


In the study, feelings of sadness tended to last longer than happiness. Also, the less patients remembered about the movies, the longer their sadness lasted, according to the research published in the September issue of the journal Cognitive and Behavioral Neurology.


The results support the need for relatives and health care providers of Alzheimer's patients to avoid causing negative emotions and to try to promote positive feelings, Guzman-Velez' team said.


More information


The Alzheimer's Association offers advice for Alzheimer's patient caregivers.


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American Doctor Exposed to Ebola Admitted to NIH Hospital

By Dennis Thompson

HealthDay Reporter



MONDAY, Sept. 29, 2014 (HealthDay News) -- Another American doctor exposed to the Ebola virus while working in West Africa was admitted Sunday to a hospital at the National Institutes of Health in suburban Washington, D.C.


The unidentified patient was working at an Ebola treatment unit in Sierra Leone when exposed to the highly lethal virus that has been ravaging four West African nations for months.


The patient was admitted to the NIH Clinical Center's special clinical studies unit "out of an abundance of caution," the agency said in a news release. The unit's staff is "trained in strict infection control practices optimized to prevent spread of potentially transmissible agents such as Ebola," the release said.


Dr. Anthony Fauci, director of the NIH's National Institute of Allergy and Infectious Diseases, wouldn't discuss details about the patient. But he told the Associated Press that exposure to the Ebola virus doesn't automatically mean someone will become sick.


"When someone is exposed, you want to put them into the best possible situation so if something happens you can take care of them," Fauci said.


The patient poses minimal risk to the NIH staffers and the public, the news release said.


The patient is the fifth U.S. health care professional exposed to the Ebola virus while working in West Africa.


Three others who became infected with the virus have recovered, while a fourth continues to undergo treatment at Emory University Hospital in Atlanta.


The third American Ebola patient to become infected -- a medical missionary -- left a Nebraska hospital on Thursday, free of the virus.


Treatments given to Dr. Rick Sacra, 51, included doses of an experimental drug and blood transfusions from a fellow U.S. medical missionary who also survived infection with the virus.


"The CDC [U.S. Centers for Disease Control and Prevention] has declared me safe and free of virus," Sacra said during a Thursday morning news conference at Nebraska Medical Center in Omaha. "Thank God. I love you all."


Sacra said his friend and fellow medical missionary and Ebola survivor, Dr. Kent Brantly, "communicated with me about a week ago and let me know in no uncertain terms that this was not going to be a quick recovery. So I have to take things one day at a time." Brantly gave blood to Sacra in the hope that antibodies to the Ebola virus would aid Sacra in his recovery.


Sacra received two transfusions of blood serum from Brantly, the first American to be infected with the virus during the West African outbreak. The men are good friends and both work for missionary groups active in the fight against Ebola in West Africa.


Nebraska hospital officials said Thursday that they don't know what helped Sacra survive his ordeal -- the experimental drug, the transfusions, the supportive care provided by doctors and nurses, or the combination of all three.


Both Brantly, 33, and another American aid worker, Nancy Writebol, 59, made a full recovery from Ebola following treatment with another experimental drug called ZMapp at Emory University Hospital in Atlanta.


The Ebola epidemic in West Africa is the worst outbreak ever of the disease. So far, an estimated 6,500 people have become infected and nearly 3,100 have died in the countries of Guinea, Liberia, Nigeria and Sierra Leone, according to the World Health Organization.


The epidemic could strike as many as 1.4 million people by mid-January unless the global community mounts a rapid response to the crisis, according to estimates by the CDC.


More information


For more on the Ebola virus, visit the U.S. Centers for Disease Control and Prevention.


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After-School Exercise Yields Brain Gains: Study

By Tara Haelle

HealthDay Reporter



MONDAY, Sept. 29, 2014 (HealthDay News) -- Regular daily exercise appears to improve children's attention and multi-tasking skills, according to a new study.


Elementary school-age students who participated in an after-school program with plenty of physical activity showed greater improvements in several areas of so-called "executive function" than similar students who did not participate.


Executive function refers to a range of mental or "cognitive" skills that include memory, focus, attention and the ability to switch back and forth between tasks.


Lead researcher Charles Hillman said that students who had the highest attendance in the program saw the biggest gains in mental skills.


"I think these are the hardest evidence we have available that time spent in physical activities, which would include physical education and recess, not only doesn't detract from academic goals, but it might enhance academic performance," said Hillman, a professor of kinesiology and community health at the University of Illinois at Urbana-Champaign.


The findings were published online Sept. 29 and in the October print issue of the journal Pediatrics.


The researchers randomly assigned 221 children, aged 7 to 9, to either the after-school program or a wait-list for the program. The after-school program occurred for nearly all of the school year (150 days). Over two hours, physical activity alternated with rest periods, resulting in about 70 minutes of moderate to vigorous exercise every weekday, Hillman said.


The children took tests to measure their "inhibition" and their "cognitive flexibility," which is basically their ability to switch between different tasks successfully, such as reading something and then answering questions about that reading, Hillman said.


Inhibition involves two types of thinking skills, Hillman explained: the ability to ignore distractions in the environment to focus on something specific, and the ability to stop a well-learned response quickly when necessary.


If a child automatically starts to ride his bicycle across a street when a light turns green, for example, a strong inhibition response refers to how quickly he can prevent himself from going forward when he notices a car running the red light.


Although children in both the after-school program and the wait-list group experienced improvements in physical fitness, inhibition and cognitive flexibility, the after-school program participants made bigger gains in all three areas.


The program participants also showed improvements in attention that were not seen in the wait-list group, and they had smaller gains in body mass index (BMI) than the wait-list students. BMI is a measurement of body fat based on height and weight.


Because the study directly compared two similar groups of children, the findings support the idea that the physical activity actually caused the brain improvements, though it's less clear how physical activity improves thinking skills, the experts said.


"From a brain structure perspective, we know that regions of the brain gain volume with fitness intervention from studies with older adults," Hillman said, though that does not mean increased volume leads to better thinking.


Meanwhile, other studies have found changes in the way neurotransmitters work in the brain after physical activity, and how exercise affects the hippocampus, the part of the brain responsible for memory and learning, he said.


Most likely, Hillman said, several different mechanisms are at work in the brain that allow physical activity to improve mental abilities.


The study was well-designed, according to an expert who was familiar with the findings.


Nathaniel Riggs, an associate professor of human development and family studies at Colorado State University in Fort Collins, said, "One important direction for future research is to actually measure physiological processes that may be able to explain these associations."


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